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A typical headache usually affects both sides of your head and varies from a mild to moderate painIt can last from 30 minutes to up to a period of one week.

The efficacy and safety of treatment with more than one dose of RIZACT Tablets within 24 hours in pediatric patients 6 to 17 years of age have not been established.

RIZACT Tablets are indicated for the acute treatment of migraine attackswith or without aurain adultsand in pediatric patients 6 to 17 years old.

RacePharmacokinetic data revealed no significant differences between African-American and Caucasian subjects.

Current theories on the aetiology of migraine headache suggest that the symptoms are due to local cranial vasodilatation and/or to the release of vasoactive and pro-inflammatory peptides from sensory nerve endings in an activated trigeminal systemThe therapeutic activity of rizatriptan in migraine can most likely be attributed to agonist effects at 5-HT 1B/1D receptors on the extracerebralintracranial blood vesselswhich become dilated during a migraine attackand on nerve terminals in the trigeminal systemActivation of these receptors results in cranial vessel constrictioninhibition of neuropeptide release and reduced transmission in trigeminal pain pathways.

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